Two surveillance indicators that potentially can be used to monitor and describe vaccine breakthrough COVID-19 cases and severe outcomes are the percentage of vaccinated persons among cases (PVC) and an IRR between unvaccinated and vaccinated patients. Getting vaccinated protects against severe illness from COVID-19, including the Delta variant, and monitoring COVID-19 incidence by vaccination status might provide early signals of changes in vaccine-related protection that can be confirmed through well-controlled vaccine effectiveness (VE) studies. Findings were consistent with a potential decline in vaccine protection against confirmed SARS-CoV-2 infection and continued strong protection against COVID-19–associated hospitalization and death. Averaged weekly, age-standardized incidence rate ratios (IRRs) for cases among persons who were not fully vaccinated compared with those among fully vaccinated persons decreased from 11.1 (95% confidence interval = 7.8–15.8) to 4.6 (95% CI = 2.5–8.5) between two periods when prevalence of the Delta variant was lower (<50% of sequenced isolates April 4–June 19) and higher (≥50% June 20–July 17), and IRRs for hospitalizations and deaths decreased between the same two periods, from 13.3 (95% CI = 11.3–15.6) to 10.4 (95% CI = 8.1–13.3) and from 16.6 (95% CI = 13.5–20.4) to 11.3 (95% CI = 9.1–13.9). jurisdictions that routinely linked case surveillance and immunization registry data.
Reported COVID-19 cases, hospitalizations, and deaths occurring among persons aged ≥18 years during April 4–July 17, 2021, were analyzed by vaccination status across 13 U.S.
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Silk, PhD 1 ( View author affiliations) View suggested citationĭownload icon Download ImageĬOVID-19 vaccine breakthrough infection surveillance helps monitor trends in disease incidence and severe outcomes in fully vaccinated persons, including the impact of the highly transmissible B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19. Reese, PhD 1 Amy Saupe, MPH 14 Jessica Sell, MPH 5 Theresa Sokol, MPH 12 Daniel Sosin, MD 15 Emma Stanislawski, MPH 15 Kelly Stevens, MS 8 Hailey Vest, MPH 13 Kelly White, MPH 13 Erica Wilson, MD 11 Adam MacNeil, PhD 1 Matthew D. Patel, PhD 1 Sargis Pogosjans, MPH 10 Heather E. Casey Lyons, MPH 2 Shelby Lyons, MPH 12 Ruth Lynfield, MD 14 Keegan McCaffrey 7 Chelsea McMullen, MS 15 Lauren Milroy, MPH 13 Stephanie Meyer, MPH 14 Leisha Nolen, MD 9 Monita R. Herlihy, MD 3 Liam Hicks, MPH 7 Corinne Holtzman, MPH 14 Mikhail Hoskins, MPH 11 Judie Hyun, MHS 6 Ramandeep Kaur, PhD 8 Meagan Kay, DVM 10 Holly Kidrowski, MPH 14 Curi Kim, MSPH 6 Kenneth Komatsu, MPH 7 Kiersten Kugeler, PhD 1 Melissa Lewis, MPH 1 B. Alden, MPH 3 Sharon Balter, MD 4 Daniel Bertolino, MPH 5 David Blythe, MD 6 Shane Brady, MPH 7 Betsy Cadwell, MSPH 1 Iris Cheng, MS 5 Sherri Davidson, PhD 8 Janelle Delgadillo 9 Katelynn Devinney, MPH 5 Jeff Duchin, MD 10 Monique Duwell, MD 6 Rebecca Fisher, MPH 4 Aaron Fleischauer, PhD 11 Ashley Grant, MPH 12 Jennifer Griffin, PhD 4 Meredith Haddix, MPH 4 Julie Hand, MSPH 12 Matt Hanson, MD 10 Eric Hawkins, MS 13 Rachel K. Suthar, PharmD 2 Rachel Severson, MS 3 Nisha B.
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